We sell electronic versions of service and user manuals, part lists, schematic diagrams for home and professional audio-visual equipment, PCs and other electrical appliances. 000 tp link mc220l pdf in our growing collection! Quazepam is indicated for the treatment of insomnia including sleep induction and sleep maintenance.

Quazepam is used for short-term treatment of insomnia related to sleep induction or sleep maintenance problems and has demonstrated superiority over other benzodiazepines such as temazepam. It had a fewer incidence of side effects than temazepam, including less sedation, amnesia, and less motor-impairment. Quazepam is effective as a premedication prior to surgery. Quazepam has fewer side effects than other benzodiazepines and less potential to induce tolerance and rebound effects. Tolerance may occur to quazepam but more slowly than seen with other benzodiazepines such as triazolam. No firm conclusions can be drawn, however, whether long-term use of quazepam does not produce tolerance as few, if any, long-term clinical trials extending beyond 4 weeks of chronic use have been conducted.

Benzodiazepines require special precaution if used in the during pregnancy, in children, alcohol or drug-dependent individuals and individuals with comorbid psychiatric disorders. Quazepam and its active metabolites are excreted into breast milk. Accumulation of one of the active metabolites of quazepam, N-desalkylflurazepam, may occur in the elderly. A lower dose may be required in the elderly. Quazepam is more tolerable for elderly patients compared to flurazepam due to its reduced next day impairments. However, another study showed marked next day impairments after repeated administration due to accumulation of quazepam and its long-acting metabolites.

Thus the medical literature shows conflicts on quazepam’s side effect profile. Quazepam is selective for type I benzodiazepine receptors containing the α1 subunit, similar to other drugs such as zaleplon and zolpidem. As a result, quazepam has little or no muscle relaxant properties. 2-Oxoquazepam, a major active quazepam metabolite. Quazepam has an absorption half-life of 0.

4 hours with a peak in plasma levels after 1. It is eliminated both renally and through feces. The active metabolites of quazepam are 2-oxoquazepam and N-desalkyl-2-oxoquazepam. The N-desalkyl-2-oxoquazepam metabolite has only limited pharmacological activity compared to the parent compound quazepam and the active metabolite 2-oxoquazepam. The absorption rate is likely to be significantly reduced if quazepam is taken in the fasted state reducing the hypnotic effect of quazepam. If 3 or more hours have passed since eating food then some food should be eaten before taking quazepam.

Quazepam modulates specific GABAA receptors via the benzodiazepine site on the GABAA receptor. This modulation enhances the actions of GABA, causing an increase in opening frequency of the chloride ion channel which results in an increased influx of chloride ions into the GABAA receptors. Quazepam has potent sleep inducing and sleep maintaining properties. Studies in both animals and humans have demonstrated that EEG changes induced by quazepam resemble normal sleep patterns whereas other benzodiazepines disrupt normal sleep. Quazepam is a drug with the potential for misuse.

Two types of drug misuse can occur either recreational misuse is where the drug is taken to achieve a high or when the drug is continued long term against medical advice. Evaluation of the safety and efficacy of quazepam for the treatment of insomnia in psychiatric outpatients”. Pharmacological studies with quazepam, a new benzodiazepine hypnotic”. Selective affinity of 1-N-trifluoroethyl benzodiazepines for cerebellar type 1 receptor sites”. BZ-1 receptors in the rat brain”. Quazepam and temazepam: effects of short- and intermediate-term use and withdrawal”. Short-term study of quazepam 15 milligrams in the treatment of insomnia”.

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